Symbol Name ID |
Rasgrp1
RAS guanyl releasing protein 1 MGI:1314635 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Defective T cell proliferation |
Decreased lymphocyte proliferation in response to mitogen |
Increased circulating IgA level |
Decreased circulating IgG level |
Increased circulating IgG level |
Increased circulating IgM level |
Autoimmune hemolytic anemia |
Increased proportion autoreactive unresponsive CD21-/low B cells |
Abnormal CD4:CD8 ratio |
Decreased proportion of CD4-positive T cells |
Autoimmune thrombocytopenia |
Lymphadenopathy |
Cervical lymphadenopathy |
Mediastinal lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Anti-thyroglobulin antibody positivity |
Anti-thyroid peroxidase antibody positivity |
Antinuclear antibody positivity |
Recurrent infections |
Recurrent lower respiratory tract infections |
Disease(s) Associated with RASGRP1 | |||||||||||||||||||||
immunodeficiency 64 |
Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
decreased thymocyte number |
enlarged spleen |
increased spleen weight |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal positive T cell selection |
abnormal double-positive T cell morphology |
increased neutrophil cell number |
increased B-1b cell number |
increased plasma cell number |
decreased B cell number |
increased B cell number |
increased NK cell number |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta memory T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta memory T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased single-positive T cell number |
increased T cell number |
increased single-positive T cell number |
abnormal T cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal immunoglobulin level |
increased IgA level |
increased IgE level |
increased IgG1 level |
increased IgG level |
decreased IgM level |
increased IgM level |
increased immunoglobulin level |
abnormal T cell physiology |
abnormal immune system cell morphology |
abnormal immune system organ morphology |
abnormal lymph node morphology |
enlarged lymph nodes |
abnormal immune system physiology |
abnormal humoral immune response |
autoimmune response |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
glomerulonephritis |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1lag/Rasgrp1lag | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m1Anu/Rasgrp1m1Anu | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m1Btlr/Rasgrp1m1Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m2Anu/Rasgrp1m2Anu | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m2Btlr/Rasgrp1m2Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m3Btlr/Rasgrp1m3Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1M4Btlr/Rasgrp1M4Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m5Btlr/Rasgrp1m5Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1tm1Jstn/Rasgrp1tm1Jstn | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Rasgrp1m1Anu/Rasgrp1+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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